Chronic heart failure with reduced ejection fraction

Research Review E-Learning Module


Chronic heart failure with reduced ejection fraction

This Research Review E-Learning Module is intended for New Zealand pharmacists and covers the use of angiotensin receptor neprilysin inhibitors (ARNIs) in heart failure with reduced ejection fraction. It is based on the Research Review Product Review of sacubitril/valsartan (Entresto®).

Before starting the module please read the Research Review Product Review publication, accessed through the link below:

to access the quiz source material
Product Review - Sacubitril/valsartan (Entresto
®) Product Review

The PDF can be viewed on screen, saved and printed through the link above. 

This E-Learning Module covers:

  • Heart failure epidemiology & burden of disease
  • Angiotensin receptor neprilysin inhibitors (ARNIs)
  • Mechanism of action of ARNIs
  • Indications and funding for sacubitril/valsartan
  • Pharmacological properties of sacubitril/valsartan
  • Efficacy & safety of sacubitril/valsartan
  • Patient selection for sacubitril/valsartan
  • Dosing & titration of sacubitril/valsartan

Learning outcomes

After completing this module you should have an improved understanding of:

  • Heart failure epidemiology & burden of disease
  • Angiotensin receptor neprilysin inhibitors (ARNIs)
  • Mechanism of action of ARNIs
  • Indications and funding for sacubitril/valsartan
  • Pharmacological properties of sacubitril/valsartan
  • Efficacy & safety of sacubitril/valsartan
  • Patient selection for sacubitril/valsartan
  • Dosing & titration of sacubitril/valsartan

Contributing experts

Expert commentary is provided by Dr Raewyn Fisher, cardiologist at Waikato DHB, clinical director of the Waikato community-based Heart Failure Service and current Chair of the Heart Failure Working Group of the NZ Cardiac Society. 

Module questions have been developed by Dr Chris Tofieldwho works in primary care skin cancer treatment, is clinical advisor at Bay of Plenty District Health Board, and consultant to Research Review.


Accreditation number: 2020/03; Expiry 11/02/2022. This online learning activity has been accredited by PSNZ ENHANCE for 1 hour of group 2 learning and pharmacists may allocate 2 group 2 points on successful completion of this learning activity evidenced by receipt of Research Review Certificate of Completion.


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